Comparison of Two Routes of Administration of a Multimodal Analgesic Protocol in Postoperative Cesarean Section

• Status: Completed
• Trial end date: 2015-06-30
• Target enrollment: 0
• Participant gender: Female

Summary

Many drugs with various mechanisms of action are used for postcaesarean pain relief. Although the response to pain relief is sometimes believed to be individual, it is very important to establish the most effective with the least adverse effects type of oral analgesia for women after caesarean section. Optimal pain control post-caesarean section will benefit not only the mother and her baby, but also a healthcare system. Optimal pain control may shorten the time spent in hospital after caesarean section and, therefore, reduce healthcare costs.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre de Maternité de Monastir
• Treatments: Acetaminophen; Analgesics; Nefopam; Piroxicam; Proroxan

Criteria

Inclusion Criteria:

• Pregnant in singleton pregnancy with gestational age > 34 weeks

• American society of anesthesiologists (ASA) physical status I-II.

Exclusion Criteria:

• history of gastrointestinal disorders predisposing to bleeding disorders such as ulcerative colitis,

• Crohn's disease,

• gastrointestinal cancers or diverticulitis,

• an active peptic ulcer,

• an inflammatory gastrointestinal disorder or a gastrointestinal haemorrhage,

• parturients who present preeclampsia,

• premature delivery (<32 weeks),

• constitutional or acquired coagulopathy,

• An antecedent of hemorrhage of the delivery,

• a hemorrhagic complication postoperatively,

• Anemia (hemoglobin less than 8g / 100ml),

• conversion of spinal anesthesia into general anesthesia,

• women with severe medical conditions: renal failure (preoperative creatinine clearance <30ml / min), heart or liver failure.