Comparison of Two Treatments for Post-Traumatic Stress Disorder

• Status: Completed
• Trial end date: 2011-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will compare the short- and long-term effectiveness of two different treatments for people with post-traumatic stress disorder.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Case Western Reserve University
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Sertraline

Criteria

Inclusion Criteria:

• DSM-IV diagnosis of PTSD

• Experienced traumatic event at least 12 weeks prior to study entry

• Willingness to discontinue current CBT or antidepressant treatment

Exclusion Criteria:

• Current diagnosis of schizophrenia or delusional disorder

• Medically unstable bipolar disorder, depression with psychotic features, or depression requiring psychiatric treatment

• Current diagnosis of alcohol or substance dependence within 3 months prior to study entry

• Ongoing intimate relationship with the perpetrator of the traumatic event

• History of nonresponse to either CBT or sertraline

• Medical contraindication for sertraline