Comparison of a "Step-Up" Versus a "Step-Down" Treatment Strategy for Patients With New Onset Dyspepsia in General Practice (The DIAMOND-Study)

• Status: Completed
• Trial end date: 2007-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study was to determine which treatment strategy, the step-up or the step-down treatment strategy, is the most cost-effective treatment for patients with new onset dyspepsia in primary care.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Radboud University
• Collaborator: ZonMw: The Netherlands Organisation for Health Research and Development
• Treatments: Aluminum Hydroxide; Antacids; Anti-Ulcer Agents; Histamine H2 Antagonists; Magnesium Oxide; Pantoprazole; Proton Pump Inhibitors; Ranitidine; Ranitidine bismuth citrate

Criteria

Inclusion Criteria:

• Presence of a new episode of dyspepsia, defined as episodic or persistent symptoms including abdominal pain or discomfort and which are, in the opinion of the general practitioner, referable to the upper gastrointestinal tract.

• Over 18 years of age

• Informed consent (written) given.

Exclusion Criteria:

• Use of prescribed acid suppressive medication during 3 months before consult

• Investigated by upper gastrointestinal endoscopy one year before inclusion

• Malignancy

• Contraindication to the study medication

• Pregnancy

• Alarming symptoms like weight loss, bleeding, and disturbed food passage

• Patients with insufficient comprehension of the Dutch language