Comparison of the Analgesic Effect of 2 Shoulder Infiltrations

• Status: Not yet recruiting
• Trial end date: 2026-12-01
• Target enrollment: 0
• Participant gender: All

Summary

For patients suffering of osteoarthritis, only analgesic treatments such as anti-inflammatory drugs and cortisone infiltrations provide significant but temporary relief of their pain. The objective is to compare the analgesic effect of 2 infiltrations: Cingal (sodium hyaluronate and triamcinolone) versus cortisone (triamcinolone). It is anticipated that the Cingal infiltration will have a greater analgesic effect than a simple cortisone infiltration in patients with moderate to severe osteoarthritis of the shoulder.

Method:

• Randomized controlled trial

• Monocentric

• Randomization will be done using sealed envelopes

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)
• Treatments: Cortisone; Hyaluronic Acid; Triamcinolone; Triamcinolone Acetonide; Triamcinolone diacetate; Triamcinolone hexacetonide

Criteria

Inclusion Criteria:

• A clinical examination that confirms the radiological diagnosis of moderate to severe primary shoulder osteoarthritis, stage II and above, according to the Samilson-Prieto classification.

• Patients aged between 20 and 90 years.

• A patient with bilateral shoulder osteoarthritis will choose the side of the infiltration, only one side can be chosen to participate in the study.

• The patient must have a clinical pain threshold of a minimum of 4/10 on the visual analogue scale.

• The patient must have the cognitive ability to read and fill out the questionnaires.

• The patient must be able to read and understand French or English

Exclusion Criteria:

• Presence of a transfixing rotator cuff tear assessed on MRI.

• No previous shoulder reconstruction surgery.

• Pregnant woman.

• A patient who has received a cortisone infiltration within 6 months prior to the start of the study.

• A patient who has received a platelet-rich plasma or a hyaluronic acid infiltration within 12 months prior to the start of the study.

• Diagnosis of avascular necrosis.

• Disease affecting the studied joint (systemic inflammatory disease, history of septic arthritis, osteonecrosis, etc.)

• Suspicion or presence of active local infectious process.

• Presence or suspicion of neoplasia or local metastasis.

• Severe trauma to the shoulder ( ≤ 3 months)

• Significant cognitive impairment or insufficient language proficiency to adequately answer the questionnaires.

• Any other serious medical condition that does not allow participation in the study or may be a contraindication to cortisone injection.