Comparison of the Antihypertensive Efficacy of Valsartan and Enalapril After Missing One Dose

• Status: Completed
• Trial end date: 2007-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study was designed in order to evaluate the blood pressure lowering effect of valsartan compared to enalapril over 24 hours after skipping one daily dose. Both drugs act on the renin-angiotensin-aldosterone system (RAAS) and are widely use for the treatment of hypertension. Previous studies had a significant limitation: the effect of a missing dose was not evaluated after the whole 24 hours post missing dose period (48 hours after last taken dose), and as a result, it does not imitate the real life situation of a missing dose.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Vigo
• Collaborators: Hospital Clinico Universitario de Santiago; Novartis
• Treatments: Antihypertensive Agents; Enalapril; Enalaprilat; Valsartan

Criteria

Inclusion Criteria:

• Essential hypertension (grade 1-2)

Exclusion Criteria:

• Severe hypertension

• Secondary hypertension

• Grade III/IV hypertensive retinopathy

• Type 1 diabetes

• Cerebrovascular or cardiovascular event during the last 12 months prior to inclusion.

• Pregnant or lactating females

• History of malignancy.

• shift workers

• intolerant to ABPM