Comparison of the Clinical Efficacy of Naproxen, Associated or Not With Esomeprazol, in Lower Third Molar Removal

• Status: Completed
• Trial end date: 2016-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The present clinical trial randomized compared the clinical efficacy of the naproxen associated or not with esomeprazol, for the removal of lower third molars. Onset, duration of postoperative analgesia, duration of anesthetic action on soft tissues, intraoperative bleeding, hemodynamic parameters, postoperative mouth opening and wound healing at the 7th postoperative day were evaluated. For this purpose, 50 healthy volunteers underwent removal of symmetrically positioned lower third molars, in two separate appointments (one to two months apart), under local anesthesia with either articaine 4% (1:200,000 adrenaline) in a doubleblind, randomized and crossed manner.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Giovana Maria Weckwerth
• Collaborator: Fundação de Amparo à Pesquisa do Estado de São Paulo
• Treatments: Esomeprazole; Naproxen

Criteria

Inclusion Criteria:

• Need of lower third molar surgeries in similar positions

Exclusion Criteria:

• Presence of systemic diseases;

• Presence of local inflammation and/or infection;

• Any history of allergic reaction to local anesthetics, gastrointestinal bleeding or ulceration;

• Cardiovascular, kidney or hepatic diseases;

• Patients who are making use of antidepressants, diuretics or anticoagulants;

• Asthma and allergy to aspirin, naproxen or any other nonsteroidal antiinflammatory drug;

• Regular use of any nonsteroidal antiinflammatory drug,

• pregnancy or

• breast feeding.