Comparison of the Effect of Magnesium Sulfate and Dexamethasone on Postoperative Sore Throat After Spinal Surgery in Prone Position With Tracheal Intubation: a Double-blind, Randomized, Noninferiority Clinical Trial

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the effect of magnesium sulfate and dexamethasone on postoperative sore throat after spinal surgery in prone position with tracheal intubation.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Magnesium Sulfate

Criteria

Inclusion Criteria:

• ASA I-II patients aged between 20 and 65 year undergoing 1 or 2 level posterior spinal fusion in prone position with tracheal intubation

Exclusion Criteria:

• preexisting hoarseness or sore throat, upper respiratory tract infection

• steroid therapy or immunocompromised patients

• chronic treatment with calcium channel blocker or magnesium

• allergy to magnesium sulphate

• Cormack-Lehane grade 3,4 or patients who are expected to difficult intubation

• fail to tracheal intubation at first trial

• reduced kidney function

• Diabetes mellitus