Comparison of the Effectiveness of Povidone-Iodine Alone to Povidone-Iodine-Tetracycline Combination
Status:
Recruiting
Trial end date:
2021-03-31
Target enrollment:
Participant gender:
Summary
Title of study: Comparison of the Effectiveness of Povidone-Iodine alone to
Povidone-Iodine--Tetracycline Combination for Chemical Pleurodesis in Malignant Pleural
Effusion.
Research design: Prospective Randomized Controlled Clinical Trial. Background: Malignant
pleural effusion (MPE) is commonly encountered in clinical practice among patients with
malignancy. In addition to its association with major morbidities, it also poses a high risk
of recurrence following drainage. Chemical pleurodesis is often required to achieve pleural
adhesion and obliteration of the pleural space to prevent such recurrence. Several agents are
in common use for chemical pleurodesis with mixed effectiveness.