Comparison of the Effectiveness of Treatment With Mifepristone and Misoprostol at the Same Time Compared to the Administration of Drugs at a 48-hour Interval for Medical Abortion.

• Status: Active, not recruiting
• Trial end date: 2021-12-30
• Target enrollment: 0
• Participant gender: Female

Summary

Medical termination of pregnancy is a common and safe alternative to surgical termination of pregnancy(8). The current protocol in the investigators unit includes oral administration of Mifepristone 600 mg and oral Misoprostol 400 mcg in a time interval of 48 hours. There is little data to compare the efficacy of concomitant administration of both drugs and different time intervals.

This study evaluates the success rate and side effects of medical termination of pregnancy while both drugs are administrated concomitantly in comparison to interval of 48 hours between the drugs.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: HaEmek Medical Center, Israel
• Treatments: Mifepristone; Misoprostol

Criteria

Inclusion Criteria:

• intrauterine singleton pregnancy of less than 49 days, reassured by ultrasound examination

• patient who desire to terminate their pregnancy and have approval of the committee for termination of pregnancy

• patient who gave their consent to have a surgical abortion eventual if needed

Exclusion Criteria:

• contraindication to Mifepristone or Misoprostol

• suspected ectopic pregnancy

• systemic treatment with steroids

• adrenal insufficiency

• heart and blood vessels disease

• coagulopathy or use of anti-thrombotic agents

• uncontrolled asthma

• liver or kidney insufficiency

• anorexia

• intrauterine device

• breastfeeding