Comparison of the Effects of Dexmedetomidine and Propofol on the Cardiovascular Autonomic Nervous System During Spinal Anesthesia

• Status: Recruiting
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Spinal anesthesia induces bradycardia and hypotnesion, because itself decreases parasympathetic activity and increases sympathetic activity. These imbalance of autonomic nervous system can be measured by heart rate variability. Propofol and dexmedetomidine, which are used for sedation during spinal anesthesia, also affect autonomic nervous system, but the exact effects are not well known. The purpose of this study is measuring the effects of propofol or dexmedetomidine on autonomic nervous system in spinal anesthesia.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ajou University School of Medicine
• Collaborator: Ilsung Pharmaceuticals CO.,LTD.
• Treatments: Anesthetics; Dexmedetomidine; Propofol

Criteria

Inclusion Criteria:

• age 20~60 years old

• Scheduled lower extremity surgery under spinal anesthesia

Exclusion Criteria:

• Arryhthmia

• Uncooperative patients

• Diabetes

• On medication: beta blocker, psychiatric medicine

• Thyroid function abnormality