Comparison of the Effects of Fentanyl, Oxycodone, Butorphanol on Gastrointestinal Function

• Status: Recruiting
• Trial end date: 2020-07-31
• Target enrollment: 0
• Participant gender: Female

Summary

Postoperative ileus (POI) is a transient loss of coordinated peristalsis precipitated by surgery and exacerbated by opioid pain medication.So,how to provide patients with ideal analgesia without affecting the recovery of postoperative gastrointestinal function?This was a prospective randomized controlled study. A total of 105 patients who were scheduled for laparoscopic hysterectomy were randomly selected from The First Affiliated Hospital with Nanjing Medical University by random number table. These patients were randomly divided into three groups: fentanyl(F) group, oxycodone(O) group and butorphanol(B) group.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The First Affiliated Hospital with Nanjing Medical University
• Treatments: Butorphanol; Fentanyl; Oxycodone

Criteria

Inclusion Criteria:

1. patients who were scheduled for laparoscopic hysterectomy from W&C BRANCH HOSPITAL OF JIANGSU PROVINCE HOSPITAL

2. American Society of Anesthesiologists (ASA) physical status classification 1 to 2,

3. Women aged 40-65

4. Weight 50-80 kg

Exclusion Criteria:

1. History of opioids abuse and allergy and contraindication to opioid drugs

2. bronchial asthma; coronary heart disease; severe hypertension; diabetes mellitus;

3. hepatic, and renal dysfunction (glutamyl aminotransferase> 40U or aspartate aminotransferase> 35U; urea nitrogen> 8.2 μmol / L, creatinine> 133 μmol / L),

4. History of brain damage or psychiatric disease

5. Patients with coagulopathy (PT> 17 seconds or activated partial thromboplastin time (APTT)> 47 seconds);

6. pregnant or lactating women;

7. Those with long-term constipation;

8. History of digestive diseases;

9. history of gastrointestinal disease (peptic ulcer disease, Crohn's disease, or ulcerative colitis)

10. Participants in other drug trials in the past three months. （11）After randomization and allocation, patients were withdrawn if laparoscopy was converted to open surgery or if they required reinvestigation for postoperative bleeding.