Comparison of the Effects of Nasal Steroids and Montelukast on Olfactory Functions in Patients With Allergic Rhinitis
Status:
Completed
Trial end date:
2014-10-01
Target enrollment:
Participant gender:
Summary
The investigators aimed to evaluate by the Sniffin' Sticks test the effects on olfactory
functions of nasal steroids and leukotriene antagonists used for allergic rhinitis.Thirty
patients with seasonal were included in this study. Patients were randomly divided into three
groups of 10 patients; group 1 received montelukast sodium and mometasone furoate therapy,
group 2 received only montelukast, and group 3 only mometasone furoate. Patients' olfactory
functions were determined using the Sniffin' Sticks olfactory test before and after a month
treatments.
Threshold, discrimination, identification, and TDI values were not significantly different
among the groups before treatment. For Group 1 and Group 3 patients, there were statistically
significant differences in threshold, discrimination, identification, and TDI values before
and after treatment (p < 0.05) (Wilcoxon signed ranks analysis) For Group 2 patients, the
before and after treatment values of threshold, discrimination, identification, and TDI
showed no significant differences (p > 0.05). According to the findings of our study, MF is
superior to montelukast in improving olfactory function. Although montelukast has been shown
to be effective against AR symptoms, its effect on olfactory function was not demonstrated in
this study.