Comparison of the Effects of Neostigmine With Sugammadex on Postoperative Nausea and Vomiting.
Status:
Completed
Trial end date:
2015-01-01
Target enrollment:
Participant gender:
Summary
Postoperative nausea and vomiting is one of most common complications after general
anesthesia. Female sex, history of postoperative nausea and vomiting, motion sickness, non
smoker status, opioid administration are known as risk factors for developing postoperative
nausea and vomiting.
It has been suggest that antagonism of residual neuromuscular block with a mixture of
neostigmine and atropine at the end of the surgery increases the risk of postoperative nausea
and vomiting.
Sugammadex is a very safe drug with almost no serious adverse effects. The known adverse
effects include slight coughing, movement, an altered taste sensation in the mouth, transient
prolongation of the QT interval, hypersensitivity, and a short term prolongation of the
activated partial thromboplastin time.
The aim of this study was to compare the sugammadex versus neostigmine plus atropine for
reversal of rocuronium induced neuromuscular blockade in terms of incidence of postoperative
nausea and vomiting.