Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Artery Surgery
Status:
Unknown status
Trial end date:
2006-02-01
Target enrollment:
Participant gender:
Summary
This will be a prospective, randomized, double-blinded, cross-over clinical trial to compare
the effects of phenylephrine or norepinephrine on cardiac function during carotid artery
surgery in patients under general anesthesia. The effect of the vasopressor on cardiac
function will be measured using electrocardiography, transesophageal echocardiography and
cardiac troponin I intraoperatively and postoperatively. We will use a cross-over pattern
since both drugs exhibit rapid onset and short duration of action. We hypothesize that there
will be less myocardial ischemia associated with the use of norepinephrine when compared with
phenylephrine during carotid artery surgery.