Comparison of the Efficacy of Paracetamol and Ibuprofen in the Management of Fever in Sepsis Patients

• Status: Recruiting
• Trial end date: 2024-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized double-blind controlled study with the primary aim of scientifically evaluating the potential effects of paracetamol and ibuprofen in the management of sepsis by comparing their fever-reducing efficacy in septic patients. Sepsis is recognized as a severe form of systemic inflammatory response syndrome (SIRS) characterized by organ dysfunction resulting from severe infections. This study aims to address a significant aspect of fever management in septic patients by objectively assessing the fever-reducing potential of paracetamol and ibuprofen.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ankara City Hospital Bilkent
• Treatments: Acetaminophen; Ibuprofen

Criteria

Inclusion Criteria:

• 18 years of age or older

• Under 80 years of age

• Willing to participate in the study

• Diagnosed with sepsis according to the latest current guidelines

• Having a fever >38°C

• With no known history of adverse reactions to the active ingredient of the medication to be used"

Exclusion Criteria:

• Under 18 years of age or over 80 years of age

• Not willing to participate in the study

• With a known history of adverse reactions to study medications

• Having a fever <38°C

• Pregnant individuals

• Individuals with advanced systemic illness

• Those with malignancies

• Patients with chronic liver and kidney disease

• Using sedative and analgesic neuro-psychiatric drugs

• With a history of psychological and neurological diseases"