Comparison of the Impact of Diet vs Thiazide in BMD in Children With Idiopathic Hypercalciuria

• Status: Unknown status
• Trial end date: 2020-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The investigator's objective is to compare and evaluate the impact of nutritional treatment vs. pharmacological treatment (hydrochlorothiazide) in bone mineral density in children with idiopathic hypercalciuria.

A randomized, open-label, one-year follow-up study will be conducted in children aged 5 to 21 years with a confirmed diagnosis of idiopathic hypercalciuria or lithiasis, excluding those patients with secondary hypercalciuria (primary hyperoxaluria, treatment with vitamin D, Bartter syndrome, primary hyperparathyroidism), previous kidney transplantation. The impact of diet (hyposodic, calcium intake according to DIR for age, normal protein intake and high water intake) will be evaluated vs. the pharmacological treatment (hydrochlorothiazide) on bone mineral density.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital Infantil de Mexico Federico Gomez
• Treatments: Hydrochlorothiazide

Criteria

Inclusion Criteria:

• Clinical diagnosis of idiopathic hypercalciuria

• Man or women

• 5 to 21 years

Exclusion Criteria:

• Clinical diagnosis of secondary hypercalciuria (primary hyperoxaluria, treatment with vitamin D, Bartter syndrome, primary hyperparathyroidism)

• Previous kidney transplant

• Clinical diagnosis of kidney disease.

• Vitamin D intake (more than 800 mg/day)