Overview

Comparison the Hemodynamics Effects Between Dexmedetomidine and Propofol in Major Abdominal Surgical Patients

Status:
Unknown status

Trial end date:
2012-12-01

Target enrollment:
0

Participant gender:
All

Summary

The alpha2 agonist dexmedetomidine is a new sedative agent combined with the analgesic qualities and lack of respiratory depression. Patients sedated with dexmedetomidine could be easily roused, these advances shows dexmedetomidine may be a effective and safe sedative agent. But some studies showed some adversely effects of dexmedetomidine on haemodynamics (such as bradycardia, hypotension), the investigators want to further research the effects of dexmedetomidine on haemodynamics, such as Cardiac Output (CO), Systemic Venous Resistance Index(SVRI), and so on. Propofol is widely used sedative agent in ICU, it also has adversely effects like bradycardia and hypotension, so the investigators want to compare the effect of dexmedetomidine with propofol on haemodynamics after major abdominal surgery. Expect to further research the mechanism of haemodynamics of dexmedetomidine.

Accepts Healthy Volunteers?

Details

Lead Sponsor:

First Affiliated Hospital, Sun Yat-Sen University

Treatments:

Benzocaine
Dexmedetomidine
Propofol

Criteria

Inclusion Criteria:

1. Postoperative patients of major abdominal surgery

2. Age ≧ 18

Exclusion Criteria:

1. heart rate ≤ 50 bpm

2. allergy with dexmedetomidine or propofol

3. pregnancy