Conbercept in Choroidal Neovascularization Secondary to Uveitis

• Status: Unknown status
• Trial end date: 2018-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators hypothesize that it is safe and effective to treat patients with choroidal neovascularisation (abnormal blood vessels growing under the retina) secondary to uveitis with Conbercept.

This will be a randomized, placebo-controlled trial. 20 patients will receive three injections of Conbercept into the affected eye (and repeated injections if required), and 20 patients will receive three sham injections requiring no needle stick, but making the patient unaware of whether or not he received active treatment.

Outcome of the two treatment groups will be compared after one year.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Chongqing Medical University

Criteria

Inclusion Criteria:

• Patient with uveitis (without signs of active uveitis) related CNV, whatever the cause, including multifocal choroiditis, punctate inner choroidopathy, ocular toxoplasmosis, serpiginous choroiditis, Birdshot chorioretinopathy or VKH syndrome, etc, with active primary subfoveal, retrofoveal or juxtafoveal lesions that affect the fovea as evidenced by angiography and/or OCT in the studied eye

• Total lesion area < 12 disc areas.

• Total area of CNV within the lesion must be > 50% of total lesion.

• Best corrected visual acuity of 20/40 to 20/320 in the study eye.

• Willing and able to give informed consent.

Exclusion Criteria:

• Prior treatment in the study eye with, external-beam radiation therapy, subfoveal focal laser photocoagulation, vitrectomy, or transpupillary thermotherapy or other anti VEGF treatments,

• History of submacular surgery or other surgical intervention in the study eye, glaucoma filtration surgery, corneal transplant surgery,

• Laser photocoagulation (juxtafoveal or extrafoveal) in the study eye within one month preceding baseline,

• Extracapsular extraction of cataract with phacoemulsification within three months preceding baseline, or a history of post-operative complications within the last 12 months preceding baseline in the study eye (uveitis, cyclitis, etc.),

• History of uncontrolled glaucoma in the study eye (defined as intraocular pressure ≥ 25 mmHg despite treatment with anti-glaucoma medication),

• Aphakia with absence of the posterior capsule in the study eye,

• Active intraocular inflammation (grade trace or above) in the study eye,

• Any active infection involving ocular adnexa including infectious conjunctivitis, keratitis, scleritis, endophthalmitis,

• Vitreous hemorrhage or history of rhegmatogenous retinal detachment or macular hole (Stage 3 or 4) in the study eye,

• Presence of a retinal pigment epithelial tear involving the macula in the study eye,

• Subfoveal fibrosis or atrophy in the study eye.