Concurrent Chemotherapy and Radiotherapy With Nitroglycerin in Patients With Locally Advanced Non-Small Cell Lung Cancer

• Status: Unknown status
• Trial end date: 2010-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Nitroglycerin will increase the effectiveness of treatment with induction chemotherapy and concurrent chemo-radiotherapy by reducing chemo-radio resistance through an increased oxygen pressure in tumoral tissue. The combination treatment of nitroglycerin and chemotherapy will result in longer disease-free and over-all survival in patients with locally advanced NSCLC

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Cancerología
• Treatments: Nitroglycerin

Criteria

Inclusion Criteria:

• Histopathologic diagnosis of non small-cell lung cancer

• Clinical stage IIIA and/or IIIB without pleural effusion

• ECOG functional status 0 or 1

• No renal function alteration (GFR >50%)

• No hepatic function alteration (ALT and AST less than 2 times its normal value)

• Leucocytes more than 2,000/mcl

• Hemoglobin more than 10mg/dL

• Platelets more than 100,000/mcl

Exclusion Criteria:

• Ischemic heart disease

• Abnormal electrocardiogram