The purpose of this study is to evaluate the accuracy and efficacy of using confocal laser
microlaryngoscopy (CLM) as a tool to perform non-invasive, in vivo, real time pathologic
assessment of laryngeal lesions.
In order to achieve this purpose, this study will prospectively enroll patients with clinical
evident laryngeal pathology concerning for cancer or dysplasia, who are scheduled to undergo
a formal intraoperative biopsy of their lesion. While in the operating room, prior to
performing a formal biopsy, CLM will be used to evaluate the area of pathology, surrounding
tissue, and contralateral normal tissue. Then the biopsy will be performed, as per standard
protocol, and the diagnostic results from CLM and the formal biopsy will be compared.