Consequences of Caffeine Intake in Sleep Restricted Teenagers
Status:
Not yet recruiting
Trial end date:
2024-09-01
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to systematically investigate two prominent factors in
teenagers' daily life: Caffeine and sleep restriction (SR) and their combined influence on
sleep, cognition, and behavior in healthy adolescents. The main questions it aims to answer
are:
The effects of caffeine under conditions of SR and SE:
- on sleep pressure and sleep continuity.
- on BOLD activity differences in reward related areas during a reward task (monetary
incentive delay task) and on reaction times (behavioral aspect) in the same task.
- on BOLD activity differences during a risk taking task (wheel of fortune task) and on
risky decision-making (behavioral aspect) in the same task.
Participants will be either in the SR or SE condition (between-subject). The protocol
consists of 2x of approximately one week in which a participant will receive caffeine or
placebo (within-subject) at the last two evenings.
The experiment consists of an ambulatory and a laboratory phase:
- The ambulatory phase consists of 5 nights, including 3 stabilization nights (8h sleep
opportunity) prior to 2 nights consisting of either SR with 6h sleep opportunity or SE
with 9.5h sleep opportunity. Participants will wear an actiwatch and fill out sleep
diaries during this period.
- The laboratory phase will be the 6th evening, night and morning of the protocol and will
be spent in our lab. Participants will do the following:
- treatment (caffeine vs. placebo) intake
- saliva sampling
- drug screening
- cognitive tests, including risk-taking and reward task
- filling in questionnaires (sleep diary, sleep quality, sleepiness, mood, expectancy)
- waking and sleep with EEG
The next day, participants will undergo an fMRI scan, including the following:
- resting-state scan
- structural scan
- arterial spin labeling scan
- reward task scan
- risk-taking task scan
Around the scan, participants will fill out/undergo:
- saliva sampling
- questionnaires (reward task, mood, sleepiness, expectancy)
Phase:
N/A
Details
Lead Sponsor:
Psychiatric Hospital of the University of Basel
Collaborators:
University Hospital, Basel, Switzerland University of Basel University of Liege University of Pittsburgh University of Zurich