Continuous High-Dose Intravenous Dextran Sulfate in Human Immunodeficiency Virus-Infected Individuals

• Status: Completed
• Trial end date: 1991-04-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine the safety and effectiveness of dextran sulfate when it is administered intravenously at the maximum tolerated dose (MTD) as a treatment for HIV infection in AIDS patients. The effect of dextran sulfate on platelet survival will also be assessed in 3 patients to help determine the mechanism of thrombocytopenia (low platelets) noted in all patients receiving intravenous dextran sulfate in this study.

Dextran sulfate appears to inhibit HIV in experiments in the test tube, but studies conducted in humans to determine its effect on HIV when dextran sulfate is given orally have not been conclusive. It is hoped that this study will show that dextran sulfate administered intravenously

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
• Treatments: Dextrans

Criteria

Inclusion Criteria

Concurrent Medication:

Allowed:

• Acetaminophen.

Patients must have:

-

Clinically documented AIDS or AIDS-related complex (ARC) defined as CDC group IVA or history of any of the findings that define CDC group IV subgroup C-2:

• oral candidiasis, oral hairy leukoplakia, multidermatomal herpes zoster, recurrent nontyphoidal Salmonella bacteremia, or nocardiosis.

Prior Medication:

Allowed:

• Acetaminophen.

Exclusion Criteria

Concurrent Treatment:

Excluded:

• Intramuscular injections.

Patients will be excluded from the study for the following reasons:

• Acute illness requiring hospitalization or antiviral drug therapy for treatment.

• Volunteers who have taken any antiviral medications, anticoagulants, antiplatelet medications, or any nonsteroidal anti-inflammatory drugs, except acetaminophen, within 2 weeks of study entry, or those who anticipate the need for such medication during the study.

• Positive stool guaiac at screening.

• Disorders of coagulation or any known contraindication to anticoagulation, including but not limited to gastrointestinal or other serious bleeding, major trauma or surgery within the past 2 months, stroke or suspicion of central nervous system (CNS) bleeding, Kaposi sarcoma (with or without proven gastrointestinal involvement), and any known CNS lesions that might be prone to bleed.

• Allergy to dextran sulfate or heparin.

• Acute or asymptomatic HIV infection.

Prior Medication:

Excluded:

• Antiviral medications.

• Anticoagulants.

• Antiplatelet medications.

• Any nonsteroidal anti-inflammatory drugs (except acetaminophen).

Prior Treatment:

Excluded:

• Hospitalization for acute illness.

Patients may not have any of the following diseases or symptoms:

• Allergy to dextran sulfate or heparin.

• Acute or asymptomatic HIV infection.

• Acute illness requiring hospitalization.

• Chronic anemia requiring transfusion within the past month.

• Disorders of coagulation or any known contraindication to anticoagulation, including but not limited to gastrointestinal or other serious bleeding, major trauma or surgery within the past 2 months, stroke or suspicion of central nervous system (CNS) bleeding, Kaposi's sarcoma, and any known CNS lesions which might be prone to bleed.