Continuous Versus Repetitive Sevoflurane Administration for Preconditioning

• Status: Completed
• Trial end date: 2007-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Pharmacologic preconditioning by volatile anesthetics may depend on the mode of administration. The researchers hypothesize that a continuous administration in patients scheduled for CABG surgery prebypass will be less effective in terms of attenuating myocardial cell damage compared to a repetitive administration with a double wash in/wash out schedule. A control group will receive propofol as their primary anesthetic.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Schleswig-Holstein; University of Schleswig-Holstein
• Collaborators: Abbott; Department of Anaesthesiology and Intensive Care Medicine
• Treatments: Sevoflurane

Criteria

Inclusion Criteria:

• Patients schedulded to undergo CABG surgery

• Age 18 to 80 years

• Ejection fraction > 40%

Exclusion Criteria:

• Emergency cases

• Diabetes

• Not able to give informed consent

• Ejection fraction < 40%