Contrast Agent-associated Nephrotoxicity in Intensive Care Unit Patients

• Status: Unknown status
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The use of N-acetylcysteine and ascorbic acid reduce the incidence of radiographic contrast agent induced reduction in renal function in Intensive Care Unit patients.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Thessaly
• Treatments: Acetylcysteine; Ascorbic Acid; N-monoacetylcystine

Criteria

Inclusion Criteria:

• Presence in the Intensive Care Unit

• Patients undergoing radiologic examinations with the use of IV contrast agents.

Exclusion Criteria:

• Renal failure under renal replacement therapy

• Unstable renal function ( change of serum creatinine between two subsequent days greater than 20% at least 3 days before the study)

• IV administration of contrast agent within the previous 6 days from the study

• Use of ascorbic acid or acetylcysteine during the week before the study

• Pregnancy