Initial data from COVID-19 patients suggests that one of the primary causes of death is
significant endothelial injury leading to blood clotting and impaired multiorgan
microvascular perfusion. The current study uses a safe, convenient bedside imaging tool
called contrast-enhanced ultrasound (CEUS) to estimate the extent of microvascular perfusion
impairment in the heart, kidneys and/or brain of COVID-19 pediatric patients in vivo and
assess the significance of imaging findings by correlating to clinical outcomes.
This pilot study will be conducted at one site, The Children's Hospital of Philadelphia. We
will enroll and evaluate 30 patients.