Contrast Ultrasound Perfusion Imaging in PAD With Sonazoid
Status:
Unknown status
Trial end date:
2018-07-01
Target enrollment:
Participant gender:
Summary
The measurement of limb skeletal muscle perfusion and perfusion reserve during exercise is an
approach that can assess the total impact of the complex pathophysiologic processes in
patients with limb ischemia, particularly in those with diabetes in whom distal arterial
disease and abnormal microvascular functional responses are common. This trial is designed
to: (a) optimize methods for assessment of limb perfusion at rest and during stress using
contrast-enhanced ultrasound (normal subjects) and a microbubble contrast agent that is able
to provide non-linear signal without destruction at medium acoustic pressures, and (b) to
test whether perfusion imaging provides incremental information on the severity of disease in
patients with peripheral artery disease.