Contrast-inDuced nephRotoxicity as Assessed by the KIdney Load-to-DAmage RElationship

• Status: Completed
• Trial end date: 2014-10-01
• Target enrollment: 0
• Participant gender: All

Summary

We previously demonstrated that the slope of the relationship plotting individual iodine loads against contrast-induced serum creatinine changes ( the load-to-damage relationship, LDR) characterizes the intrinsic nephrotoxicity of the contrast. Aim of the present study is to compare, through the assessment of the LDR slope, the intrinsic nephrotoxicity of two different contrast media using serum cystatin-C changes as the LDR dependent variable.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Azienda Sanitaria Locale 9, Grosseto
• Treatments: Cystatins

Criteria

Inclusion Criteria:

• Patients candidate to coronary angiography and/or angioplasty and

• Baseline creatinine clearance < 60 ml/min

Exclusion Criteria:

• Patients with STEMI

• Patients with shock

• Known allergy to contrast media

• Prior contrast administration within 1 month

• Current use of nonsteroidal anti-inflammatory drugs