Control of Emergence Blood Pressure During Craniotomy for Tumor Surgery Between Labetolol and Diltiazem

• Status: Completed
• Trial end date: 2013-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the effectiveness of the antihypertensive drugs in the control of emergence blood pressure after tumor resection craniotomy; compared between labetalol (Avexa) and diltiazem (Herbessor).

Also the investigators seek to determine the effective dose of the antihypertensive drugs and their side effects in Thai population.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mahidol University
• Treatments: Diltiazem; Labetalol

Criteria

Inclusion Criteria:

• patients who scheduled for craniotomy for tomor removal

Exclusion Criteria:

• allergic to labetalol or diltiazem

• Bradycardia < 60 beat/min

• Second or third degree heart block

• Severe asthma or severe COPD

• Brain stem tumor