Control of Fever in Septic Patients

• Status: Completed
• Trial end date: 2019-03-31
• Target enrollment: 0
• Participant gender: All

Summary

The benefits of fever treatment in critically ill patients remains unclear. The aim of the prospective, randomized clinical trial was to verify the hypothesis that the administration of ibuprofen in order to decrease the fever in septic patients without limited cardiorespiratory reserve leads to decreasing their prognosis.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Ostrava
• Treatments: Ibuprofen

Criteria

Inclusion Criteria:

• age >18 years of age

• body temperature >38.3°C within 2 consecutive hours

• anti-microbial therapy for a known or suspected infection

Exclusion Criteria:

• patients admitted after successful cardiopulmonary resuscitation (CPR)

• acute myocardial infarction

• brain injury (traumatic and non-traumatic)

• transfer from another ICU after 72 hours

• pregnancy

• antipyretic medication prior to randomization

• non-obtaining the informed consent

• moribund condition

• high risk of hemodynamic or respiratory maladaptation on the metabolic effect of fever