Bleeding is the most avoidable cause of death in trauma patients. Up to one-third of severely
injured trauma patients are found to be coagulopathic and forty percent of the mortality
following severe injury is due to uncontrollable hemorrhage in the setting of coagulopathy.
It has been established that early administration of fresh frozen plasma decreases mortality
following severe injury, replacing lost coagulation factors, improving the coagulopathy and
restoring blood volume. This study will determine if giving plasma to severely injured trauma
patients during ambulance transport versus after arrival to the hospital will help reduce
hemorrhage, thus decreasing both total blood product administration and mortality.
Phase:
Phase 2
Details
Lead Sponsor:
Denver Health and Hospital Authority
Collaborators:
U.S. Army Medical Research and Development Command U.S. Army Medical Research and Materiel Command University of Colorado, Denver