Controlled Trial: 5-day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus
Status:
Completed
Trial end date:
2005-12-01
Target enrollment:
Participant gender:
Summary
New antibiotics are required that have antibacterial activity against doxycyline resistant O.
tsutsugamushi, that can be safely used in pregnant women and children, that have a low
possibility of inducing resistance and that do not induce cross resistant to other
antibiotics. Telithromycin has been reported to be effective on Rickettsia, Batonella and
Coxiella burnetii. Therefore, telithromycin may be considered as a substitute antibiotic that
can be used safely in pregnant women and children for rickettsiosis or Orientia infection.
Our study was designed to prove the clinical usefulness of telithromycin by comparing it with
doxycycline for treating mild or moderate scrub typhus.