Overview Copanlisib With Ibrutinib for Patients With Recurrent/ Refractory Primary Central Nervous System Lymphoma (PCNSL) Status: Recruiting Trial end date: 2023-07-01 Target enrollment: Participant gender: Summary The purpose of this study is to test the safety of combined use of the study drugs, copanlisib and ibrutinib, in people with PCNSL. Phase: Phase 1/Phase 2 Details Lead Sponsor: Memorial Sloan Kettering Cancer Center