Copenhagen Acute Renal Complications After Transplantations Study Group
Status:
Completed
Trial end date:
2016-10-01
Target enrollment:
Participant gender:
Summary
Lung transplanted patients experience marked decrease in renal function post transplant
mainly due to cyclosporine induced renal changes. Calcium channel blockers may improve renal
function in cyclosporine treated transplant recipients through their effects in avoiding
cyclosporine-induced renal vasoconstriction and facilitating renal sodium output.
The aim of this study is to examine if calcium channel blockade administered before lung
transplantation prevent cyclosporine induced nephropathy.
The design is an intention to treat randomized double blinded single center study. Patients
are randomized to two groups, one that received felodipine and one that receives placebo.
Study population is all patients listed for lung transplantation in Denmark in the study
period.
Intervention is tablet felodipine titrated to 10 mg, one daily dose in 12 weeks
Primary endpoint is change in renal function as measured by glomerular filtration rate using
chromium-51 labeled ethylenediamine tetraacetic acid (51-Cr-EDTA) in the felodipine treated
group compared with the placebo group.