Copeptin After an Oral Stimulation With Macimorelin in Healthy Volunteers

• Status: Completed
• Trial end date: 2019-07-16
• Target enrollment: 0
• Participant gender: All

Summary

This study investigates stimulation of the posterior pituitary gland by oral Macimorelin (a ghrelin receptor Agonist) to be a novel diagnostic test in the polyuria-polydipsia syndrome.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Basel, Switzerland
• Treatments: Arginine Vasopressin; Tryptophan

Criteria

Inclusion Criteria:

• No medication except hormonal contraception

Exclusion Criteria:

• Body Mass Index (BMI) > 40kg/m2 or BMI < 18.5 kg/m2

• participation in a trial with investigational drugs within 30 days

• vigorous physical exercise within 24 hours before the study participation

• Alcohol intake within 24 hours before study participation

• pregnancy and breastfeeding

• Evidence of disordered drinking habits and diuresis defined as polyuria >50ml/kg body weight/24h and polydipsia >3l /24h

• a prolonged QT interval (QTc >500 ms) or concomitant treatment with drugs that prolong the QT/QTc.

• Intention to become pregnant during the course of the study

• Known allergy towards Macimorelin