Copper and Molybdenum Balance in Participants With Wilson Disease Treated With ALXN1840

• Status: Recruiting
• Trial end date: 2021-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This exploratory study will investigate the effects of ALXN1840 on copper balance in participants with Wilson disease (WD).

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Alexion Pharmaceuticals

Criteria

Inclusion Criteria:

1. Diagnosis of WD by Leipzig Criteria > 4.

2. Able to reside in the clinical research unit for intensive metabolic monitoring of copper and molybdenum.

3. Participants willing to adhere to copper/molybdenum-controlled diet during the study.

4. Willing and able to follow protocol-specified contraception requirements.

5. Capable of giving signed informed consent.

Exclusion Criteria:

1. Decompensated cirrhosis or model for end stage liver disease score > 13.

2. Modified Nazer score > 7.

3. Clinically significant gastrointestinal bleed within past 3 months.

4. Alanine aminotransferase > 2 × upper limit of normal.

5. Hemoglobin less than lower limit of the reference range for age and sex.

6. Significant medical history (current or past).

7. Previous treatment with zinc within 30 days prior to the Screening Visit.

8. Participants in renal failure, defined as in end-stage renal disease on dialysis (chronic kidney disease stage 5) or creatinine clearance < 30 milliliters/minute.