Overview

Corifollitropin Alfa Followed by hpHMG in a Long GnRH Agonist Protocol for the Treatment of Poor Ovarian Responders

Status:
Completed

Trial end date:
2013-05-01

Target enrollment:
0

Participant gender:
Female

Summary

The purpose of the present study is to examine the level of ovarian response and the pregnancy rates among poor ovarian responders treated with a novel treatment protocol with 150μg corifollitropin alfa followed by 300IU hMG in a long GnRH agonist protocol.

Phase:

Phase 2

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Universitair Ziekenhuis Brussel

Treatments:

Deslorelin
Triptorelin Pamoate

Criteria

Inclusion Criteria:

Patients should fulfill the "Bologna criteria" for poor ovarian response

At least two of the following three features must be present:

i. Advanced maternal age (≥40 years) or any other risk factor for POR (poor ovarian
response); ii. A previous POR (≤3 oocytes with a conventional stimulation protocol); iii.
An abnormal ovarian reserve test (i.e. AFC <7 follicles or AMH <1.1 ng/ml).

Two episodes of POR after maximal stimulation are sufficient to define a patient as poor
responder in the absence of advanced maternal age or abnormal ORT (ovarian reserve test).

Exclusion Criteria:

-