Correlation Between Myocardial Injury and Intestinal Flora Changes Associated With Oncology Drug Therapy and the Preventive of Probiotics

• Status: Not yet recruiting
• Trial end date: 2023-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study was to explore the relationship between early myocardial injury caused by tumor drug therapy and intestinal microbial structure changes by echocardiographic two-dimensional speckle tracking technique and intestinal microflora structure detection. The investigators will also explore prevention and treatment through randomized controlled trials to initiate early intervention before clinical symptoms appear.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University Third Hospital
• Treatments: Carboplatin; Cisplatin; Paclitaxel

Criteria

Inclusion Criteria:

• With malignant tumors

• Will receive antitumor drugs

• Could receive regular follow-up for 6 months

• Written informed consent

Exclusion Criteria:

• Satisfactory echocardiographic images could not be obtained

• Cardiomyopathy

• Coronary artery disease

• Heart failure

• Arrhythmia requiring intervention

• Moderate or severe valvular disease

• Acute myocarditis

• Refractory hypertension

• Participating in other studies of drug intervention