Correlation Between Regional Brain Volume and Response to Donepezil Treatment in AD Patients

• Status: Terminated
• Trial end date: 2008-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This study investigate the relationship between regional brain volume measured by MRI and donepezil treatment response in patients with Alzheimer's Disease.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Eisai Korea Inc.
• Treatments: Donepezil

Criteria

Inclusion criteria:

1. Over 60 years old.

2. Probable or possible Alzheimer's Disease according to the DSM-IV and NINCDS-ADRDA.

3. MMSE score of 10~24, CDR of 1~2.

4. Patients didn't take acetylcholinesterase inhibitors 4 weeks before screening.

5. Permitted drugs: antipsychiatric drug for BPSD, antidepression drug, tranquilizer, treatment drug for physical disease for example hypertension.

Exclusion criteria:

1. Uncontrolled by donepezil because of adverse events.

2. No longer continuing treatment of donepezil for refuse, drug-drug interaction etc.

3. If they have taken concomitant medication which were not allowed.