Cortical Excitability Changes Induced by Retigabine: a Transcranial Magnetic Stimulation Study

• Status: Completed
• Trial end date: 2014-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to characterize the effects of a single-dose of retigabine on cortical excitability in healthy subjects, as quantified by means of TMS.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital of Mont-Godinne
• Collaborators: GlaxoSmithKline; Université Catholique de Louvain
• Treatments: Ezogabine

Criteria

Inclusion Criteria:

• age 18-50 years

• being "healthy"

• willing to participate and able to understand study and provide informed consent

Exclusion Criteria:

• intake of psycho-active drugs (AEDS, antidepressants, benzodiazepines, neuroleptics, hypnotics, ...)

• alcohol or drug abuse

• antecedent of seizure

• contra-indication to TMS (metal in the head, skull fracture)

• contra-indication to retigabine.