Corticosteroid Effects on Asymptomatic Gadolinium-enhancing Lesions in Multiple Sclerosis
Status:
Enrolling by invitation
Trial end date:
2023-10-23
Target enrollment:
Participant gender:
Summary
to determine the rate of asymptomatic gadolinium-enhancing lesions conversion to the
non-enhancing black hole (neBHs) with or without corticosteroid pulse therapy in patients
with RRMS, and to analyze if treatment of asymptomatic gadolinium enhancement lesions has any
effect on the expanded disability status scale. The study is performed in the MS clinic of Bu
Ali Sina Hospital in Sari and Mazandaran University of Medical Sciences. 104 recurrent MS
patients are admitted based on the admission criteria. They are divided into two groups of
intervention and control based on a simple randomization block. The intervention group
received 1 gram of methylprednisolone in 500 ccs of normal saline for 5 days and the control
group received only 500 ccs of serum. After 6 months, a new MRI is taken from the patients
and the possibility of asymptomatic active plaque conversion with or without intervention is
compared in the two groups, as well as the amount of EDSS in the two groups. They do not know
whether the patient is in the control group or the intervention.