Corticosteroid Intra-articular Injection in Hands Osteoarthritis

• Status: Completed
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Objective - to evaluate the effectiveness and tolerance of intra-articular injections (IAI) of hexacetonide triamcinolone (HT) for the treatment of osteoarthritis (OA) in interphalangeal joints.

Design:randomized, controlled, double-blinded study Materials and methods: sixty patients were randomized into: the TH / lidocaine (LD) group (n=30) who underwent IAI at the most symptomatic interphalangeal joint with HT (20mg/ml) and LD 2% or the LD group (n=30) who received IAI with just LD. Patients were assessed at baseline, 1, 4, 8 and 12 weeks by a blinded observer. The following parameters regarding the affected joint were assessed: pain at rest (VASr); pain at movement (VASm); pain (VAS) during the 48 hours after the procedure; swelling (VASs); goniometry; grip and pinch strength; hand function; treatment improvement; daily requirement of paracetamol and incidence and types of local side effects after the procedure.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Federal University of São Paulo
• Treatments: Lidocaine; Triamcinolone; Triamcinolone Acetonide; Triamcinolone diacetate; Triamcinolone hexacetonide

Criteria

Inclusion Criteria:

• Hand OA

• Age over 40

• Visual analogic scale (VAS) for pain at rest between 3-8cm

• Signed informed consent term

Exclusion Criteria:

• Change in the use of oral corticosteroid or nonsteroidal antiinflammatory (NSAID) in the last 30 days

• Change in drugs for OA in the last two months

• IAI in this joints in the last three months

• Any change in treatment for OA in the hands in the last two months

• Suspicion of local and or systemic infection, and pregnancy

• Hands X-ray suggesting arthropathy of the interphalanges of other etiology

• Serious coagulation disorder