Corticosteroid vs Platelet-Rich Plasma Intra-articular Injections in the Treatment of Knee Osteoarthritis.

• Status: Recruiting
• Trial end date: 2025-04-30
• Target enrollment: 0
• Participant gender: All

Summary

This study will explore the effectiveness of intra-articular knee injections in patients with osteoarthritis by comparing Corticosteroid (triamcinolone) vs Platelet Rich Plasma (PRP).

This study is a randomized controlled trial with a sample size of one hundred and sixty patients (160). Patients would be recruited via new referrals and follow-up appointments in the Orthopaedic clinic at the UHWI (University Hospital of the West Indies) with knee osteoarthritis.

The aim of the study is to:

1. To determine if platelet-rich plasma injections are better at improving functional outcomes in the knee using Western Ontario and McMaster Universities Arthritis Index (WOMAC) when compared to intraarticular steroids.

2. To identify adverse reactions related to these injections

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The University of The West Indies
• Treatments: Triamcinolone

Criteria

Inclusion Criteria:

Kellgren and Lawrence grades 2-3 Age 50 years and older

Exclusion Criteria:

1. Patients with secondary OA:

2. History of Fractures around the knee joint i. patella ii. tibia plateau iii. intra articular distal femur

3. Bleeding diathesis

4. History of septic arthritis

5. Patients on oral steroid medications

6. Patients who received intraarticular steroid injection < 6 months before enrollment

7. Sickle Cell Disease

8. Rheumatoid arthritis

9. Patients with a diagnosis of knee OA with little or no pain

10. Patient with a diagnosis of knee OA being successfully managed with oral medications and physiotherapy

11. Knee pain not attributed to a diagnosis of OA

12. All patients who refuse to participate