Corticosteroids and Myocardial Injury in CAP (COLOSSEUM TRIAL)
Status:
Recruiting
Trial end date:
2024-09-01
Target enrollment:
Participant gender:
Summary
Community-acquired pneumonia (CAP) is often complicated by elevation of cardiac troponin, a
marker of myocardial injury, that can be isolated or associated to myocardial infarction
(MI). A retrospective study showed that corticosteroid treatment lowers incidence of MI
during the hospital-stay.
The aim of this clinical trial is to examine whether in-hospital treatment with iv
methylprednisolone (20 mg b.i.d) may reduce myocardial injury, as assessed by serum
high-sensitivity cardiac T Troponin) and eventually cardiovascular events during a short- and
long-term follow-up in patients hospitalized CAP.