Corticosteroids for the Prevention of Atrial Fibrillation After Cardiac Surgery

• Status: Terminated
• Trial end date: 2012-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Atrial fibrillation is the most common arrhythmia to occur after cardiac surgery. Inflammatory response may be one etiological factor.

We hypothesized that intravenous corticosteroid administration after cardiac surgery prevents AF after cardiac surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Kuopio University Hospital
• Collaborators: Oulu University Hospital; Tampere University Hospital
• Treatments: Cortisol succinate; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate

Criteria

Inclusion Criteria:

• Patients scheduled to undergo their first on-pump CABG, aortic valve replacement or combined aortic valve replacement and CABG were enrolled.

Exclusion Criteria:

• Previous episodes of AF or flutter

• Uncontrolled diabetes mellitus

• Systemic mycotic infection

• Active tuberculosis

• Cushing's syndrome

• Psychotic mental disorder

• Herpes Simplex keratitis

• Serum creatinine exceeding 200 µg/ml

• Patients were also excluded if they had a history of previous peptic ulcer or thrombophlebitis.