Corticosteroids in Community Acquired Pneumonea

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Low dose hydrocortisone IV in patients with CAP fastens recovery of pneumonia and prevents the development of sepsis related complications with a significant reduction in duration of mechanical ventilation

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cairo University
• Treatments: Cortisol succinate; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate

Criteria

Inclusion Criteria:

Minor criteria included

• respiratory rate > 30 bpm at admission;

• ratio of PaO2 to fraction of inspired oxygen (PaO2:FIO2 ) < 250;

• chest radiograph showing bilateral involvement or multilobar involvement;

• systolic blood pressure < 90 mm Hg; or

• diastolic blood pressure < 60 mm Hg. Major criteria included

• Requirement of MV;

• Increase in the size of opacities on chest radiograph of 50% or more at 48 hours;

• Requirement of vasopressors for more than 4 hours; or

• Serum creatinine 2 mg/dl or more. 10

Exclusion Criteria:

• Children;

• Nosocomial pneumonia;

• Hospitalisation within the previous 14 days;

• Severe immunosuppression (chronic use of systemic steroids);

• Non-steroid immunosuppressive treatment or HIV);

• Chronic chest disease; , tuberculosis, aspiration or obstructive pneumonia;

• Congestive heart failure (cerebrovascular stroke);

• Chronic renal or hepatic disease;

• Acute burn injury;

• Malignancy;

• Pregnancy; and

• Major gastrointestinal bleed within 3 months of the current hospitalization.