Cotrimoxazole Versus Amoxicillin in the Treatment of Community Acquired Pneumonia in Children Aged 2-59 Months
Status:
Completed
Trial end date:
2008-01-01
Target enrollment:
Participant gender:
Summary
The investigators hypothesized that Oral amoxicillin (25mg/kg/dose bid) given to children
aged 2-59 months with pneumonia, would lead to better clinical outcome on day three in 89.9%
of the children compared to 77.0% of children receiving oral cotrimoxazole (8 mg/kg/dose
trimethoprim, 40 mg/kg/dose sulphamethoxazole). A double blind randomized controlled trial
was conducted in the Assessment Center of Mulago Hospital. Children with non-severe pneumonia
were randomized to receive either oral amoxicillin (25 mg/kg/dose) or cotrimoxazole
(trimethoprim 8 mg/kg and sulphamethoxazole 40 mg/kg) and followed up on day 3 and 5 of
treatment. The primary outcome measures were normalization of respiratory rate by day 3 of
treatment. Secondary outcome measures were antimicrobial susceptibility to cotrimoxazole and
amoxicillin.
Phase:
Phase 3
Details
Lead Sponsor:
Makerere University
Treatments:
Amoxicillin Sulfamethoxazole Trimethoprim, Sulfamethoxazole Drug Combination