Cranberry Tablets Versus Nitrofurantoin Prophylaxis for Urinary Tract Infection Prevention After Urogynecologic Surgery

• Status: Recruiting
• Trial end date: 2022-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

We aim to compare the effectiveness of cranberry capsules versus nitrofurantoin prophylaxis in preventing urinary tract infections (UTIs) after urogynecologic surgery by conducting a double-blinded randomized clinical trial involving women with pelvic organ prolapse and/or urinary incontinence scheduled to have surgery with the Urogynecologists who comprise the Brigham and Women's Urogynecology Group.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Brigham and Women's Hospital
• Collaborator: Theralogix LLC
• Treatments: Nitrofurantoin

Criteria

Inclusion Criteria:

• Age ≥ 18

• English-speaking

• Plan for POP or UI surgery

Exclusion Criteria:

• Pregnancy

• Urethral diverticulectomy

• Urogenital fistula repair

• Sacral neuromodulation

• Congenital urogenital anomaly

• Allergy to cranberry products

• Allergy to nitrofurantoin

• Dependent on catheterization preoperatively

• Recurrent UTI's (3 or more culture proven UTI's over the past consecutive 12 months)

• Known creatinine clearance <60 mL/min

• Non-English, Non-Spanish speaking