Overview

Creatine Use and Muscle Stretching in Peripheral Artery Disease

Status:
Recruiting

Trial end date:
2021-12-01

Target enrollment:
0

Participant gender:
All

Summary

To utilize near-infrared spectroscopy to investigate if the research device, which induces muscle stretching, and creatine loading impact submaximal exercise performance in aged and PAD patients. Near-infrared spectroscopy (NIRS)-derived tissue oxygenation responses will be obtained during device placement (muscle stretch) and during a walking test (i.e., six-minute walk test). Muscle oxygenation at rest and during device placement will be assessed with Magnetic Resonance Imaging. It is hypothesized that the stretching protocol will improve both NIRS-derived tissue oxygenation and magnetic resonance-derived muscle oxygenation and that creatine supplementation will further improve phosphorus metabolite muscle performance. All patients will undergo either 4 weeks of stretch training with- or- without creatine supplementation according to previously defined creatine guidelines.

Phase:

Phase 2

Accepts Healthy Volunteers?

Accepts Healthy Volunteers

Details

Lead Sponsor:

Florida State University

Criteria

Inclusion Criteria:

1. Ankle-brachial index (ABI) of 0.90 or less in either leg or clinical diagnosis by a
medical doctor (PAD group only)

2. Stable condition for at least 3 months (PAD group only)

Exclusion Criteria:

1. Habitual exercise or cardiovascular rehabilitation program during the past 3 months

2. Critical limb ischemia

3. Blow or above-knee amputation

4. Leg pain at rest

5. Major surgery or lower extremity revascularization in the last 3 months

6. Major medical illness treatment during the prior 12 months

7. Central neurological disease

8. Limited ankle or knee joint range of motion

9. Requirement of oxygen with activity or exercise

10. Heart failure

11. Atrial fibrillation

12. Wheelchair confinement or inability to walk

13. Cognitive disorder

14. Vasculitis problems including Takayasu's arteritis, Berger's disease, collagen disease
or Reynaud's disease

15. Overt cardiovascular disease

16. Metabolic disease

17. Renal disease