Crossover Study to Compare the Pharmacokinetics of Subcutaneous and Intravenous Ceftriaxone Administration
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
The proposed study aims to assess the time above MIC (4 mg/mL), and the
pharmacokinetics/pharmacodynamics and bioavailability of 1 g ceftriaxone administered by
constant rate subcutaneous infusion over 2 hours compared with 1 g of ceftriaxone
administered as a constant IV infusion over 0.5 hours. In addition, the study will compare
the results obtained after 1 g ceftriaxone intravenous or subcutaneous administration with 2
g ceftriaxone administered subcutaneously