Cultures Before and After Decolonization in Community Dwelling Adults With Current S. Aureus Colonization
Status:
Completed
Trial end date:
2014-11-18
Target enrollment:
Participant gender:
Summary
The investigators propose to study the microbiome of the nose, throat and three skin sites in
a population without current exposure to the healthcare environment: 80 community dwelling
adults. We will characterize the microbial communities in these body sites (nose, throat,
perirectal and three skin sites) over time using culture-independent techniques. The
investigators will then "decolonize" the subjects. Subjects will receive intranasal mupirocin
and topical chlorhexidine. The investigators will then compare the microbial communities at
baseline and after decolonization within individuals. Our overall hypothesis is that the
microbial composition of these sites and the response to decolonization is influenced by the
healthcare environment and that decolonization leads to re-colonization with an increasing
proportion of Gram-negative bacilli.